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KMID : 0385020010170030179
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Korean Journal of Laboratory Animal Science
2001 Volume.17 No. 3 p.179 ~ p.186
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Nucleotide diversity of mitochondrial DNAs based on restriction cleavage patterns in Korean wild mouse
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Oh, Yang Seok
Suh, Jun Gyo/Kim, Chung Sup/Do, Sun Gil
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Abstract
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The nucleotide diversities (NDs) between the Korean wild and inbred mice were estimated based on the mitochondrial (mt) DNAs. The Korean wild mice at three localities in northeast Korea (Sokcho, Chunchon, Heangsung) were classified into two strains, M. m. molossinus and Micromys minutus. Mice mtDNAs had a total of 16-27 cleavage sites for the 8 restriction endonuclease used and digestion with 7 enzymes exhibited 2 or 3 restriction fragment patterns among the sub-species. The polymorphic fragment patterns for the seven endonucleases revealed at least three mtDNA types in the inbred and Korean wild mice examined. The three mtDNA types were designated M, m. domesticus (Do), M. m. molossinus (Mo) and micromys munutus (Mu). In Mo captured from Chunchon, Sokcho and Heangsung, no polymorphic fragment patterns of mtDNA were found with 8 restriction endonucleases. Mu captured from Chunchon and Sokcho also shows no differences in the cleavage patterns of mtDNA. The NDs for Mo and Mu mtDNAs compared to the Do mtDNAs were estimated to be about 8.8% and 28.0%, respectively. The NDs between Mo and Mu mtDNAs was 28.8%. The dendrogram for the mtDNA diversities showed a clear-cut genetic differentiation among the inbred and two types of Korean wild mice.
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